Therapeutic levels of recombinant hirudin.
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چکیده
منابع مشابه
Evaluating the Effect of Protein A Signal Peptide on Extracellular Expression of Recombinant Hirudin in E.Coli
Abstract Background and Objective: Hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. Recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis. The aim of this study was to evaluate the effect of inserting protein A signal peptide sequence of pEZZ18 plasmid on expression and secretion...
متن کاملModified plasma-based ecarin clotting time assay for monitoring of recombinant hirudin during cardiac surgery.
Recombinant hirudin (r-hirudin) is being used increasingly for therapeutic anticoagulation in patients with heparin-induced thrombocytopenia undergoing cardiovascular surgery. Although multiple laboratory methods are available for measuring r-hirudin, the ecarin clotting time (ECT) is the most commonly used for this purpose. Ecarin (extracted from snake venom) converts prothrombin to meizothrom...
متن کاملIn vivo thrombin generation and activity during and after intravenous infusion of heparin or recombinant hirudin in patients with unstable angina pectoris.
In patients with unstable angina, intravenous heparin reduces thrombin activity but does not influence thrombin generation. Recombinant hirudin, a direct thrombin inhibitor, may be more effective in inhibiting both thrombin generation and activity. We measured the plasma levels of prothrombin fragment 1+2 (a marker of thrombin generation) and fibrinopeptide A (a marker of thrombin activity) in ...
متن کاملRecombinant hirudin in patients with chronic, stable coronary artery disease. Safety, half-life, and effect on coagulation parameters.
BACKGROUND Because the specific antithrombin hirudin prevents platelet-rich arterial thrombus and accelerates thrombolysis in a variety of animal models, it has promise as antithrombotic therapy. We therefore studied the half-life, effect on anticoagulant parameters, and safety of hirudin in patients with coronary artery disease. METHODS AND RESULTS Thirty-eight men and 1 woman (age [mean +/-...
متن کاملToday's Cardiovascular Drug Development
T hrough evolution, several animal species have been endowed with salivary anticoagulants, presumably to secure their nutritional requirements for fluid blood from their prey. It has been known for centuries that the bites of leeches, certain snakes, insects, and vampire bats can result in local and systemic bleeding. The use of the medicinal leech, Hirudo medicinalis, for therapeutic bloodlett...
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ورودعنوان ژورنال:
- Haemostasis
دوره 22 6 شماره
صفحات -
تاریخ انتشار 1992